Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects.

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  • Additional Information
    • Author-Supplied Keywords:
      CD59
      complement
      diabetes
      glycation
    • NAICS/Industry Codes:
      325414 Biological Product (except Diagnostic) Manufacturing
    • Abstract:
      Type 1 diabetes is associated with anaemia. Although the underlying mechanisms remain unclear, the accompanying reticulocytosis implies that erythrocyte lifespan in the circulation is shortened. Among the factors that permit prolonged survival of erythrocytes are the membrane complement regulators. In conditions such as paroxysmal nocturnal haemoglobinuria, where erythrocyte expression of these regulators is reduced, erythrocyte survival is compromised and anaemia follows. Recentin vitroevidence indicates that one of the key membrane complement regulators, CD59, is inactivated by glycation in the presence of high concentrations of glucose or other glycating sugars. To ascertain whether glycation-induced inactivation of CD59 occurrsin vivowe examined CD59 surface expression and function on erythrocytes from a cohort with poorly controlled type 1 diabetes (hyperglycaemic) and from matched normoglycaemic controls. Although expression of CD59, assessed using polyclonal anti-CD59 antiserum, was similar in the two groups, erythrocytes from hyperglycaemic individuals were more susceptible to lysis by complement, entirely as a result of the loss of functional CD59. These data implicate glycation-induced inactivation of CD59 as a factor contributing to anaemia in type 1 diabetes. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK.
    • ISSN:
      0019-2805
    • Accession Number:
      10.1111/j.1365-2567.2004.02086.x
    • Accession Number:
      15792912
  • Citations
    • ABNT:
      DAVIES, C. S.; HARRIS, C. L.; MORGAN, B. P. Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects. Immunology, [s. l.], v. 114, n. 2, p. 280–286, 2005. Disponível em: . Acesso em: 20 nov. 2019.
    • AMA:
      Davies CS, Harris CL, Morgan BP. Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects. Immunology. 2005;114(2):280-286. doi:10.1111/j.1365-2567.2004.02086.x.
    • APA:
      Davies, C. S., Harris, C. L., & Morgan, B. P. (2005). Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects. Immunology, 114(2), 280–286. https://doi.org/10.1111/j.1365-2567.2004.02086.x
    • Chicago/Turabian: Author-Date:
      Davies, Catherine S., Claire L. Harris, and B. Paul Morgan. 2005. “Glycation of CD59 Impairs Complement Regulation on Erythrocytes from Diabetic Subjects.” Immunology 114 (2): 280–86. doi:10.1111/j.1365-2567.2004.02086.x.
    • Harvard:
      Davies, C. S., Harris, C. L. and Morgan, B. P. (2005) ‘Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects’, Immunology, 114(2), pp. 280–286. doi: 10.1111/j.1365-2567.2004.02086.x.
    • Harvard: Australian:
      Davies, CS, Harris, CL & Morgan, BP 2005, ‘Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects’, Immunology, vol. 114, no. 2, pp. 280–286, viewed 20 November 2019, .
    • MLA:
      Davies, Catherine S., et al. “Glycation of CD59 Impairs Complement Regulation on Erythrocytes from Diabetic Subjects.” Immunology, vol. 114, no. 2, Feb. 2005, pp. 280–286. EBSCOhost, doi:10.1111/j.1365-2567.2004.02086.x.
    • Chicago/Turabian: Humanities:
      Davies, Catherine S., Claire L. Harris, and B. Paul Morgan. “Glycation of CD59 Impairs Complement Regulation on Erythrocytes from Diabetic Subjects.” Immunology 114, no. 2 (February 2005): 280–86. doi:10.1111/j.1365-2567.2004.02086.x.
    • Vancouver/ICMJE:
      Davies CS, Harris CL, Morgan BP. Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects. Immunology [Internet]. 2005 Feb [cited 2019 Nov 20];114(2):280–6. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=15792912&authtype=sso&custid=s5834912