REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms.

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  • Additional Information
    • Author-Supplied Keywords:
      epigallocatechin gallate
      hyperforin
      isoflavones
      resveratrol
      sirtuins
      transcription
    • Abstract:
      Early investigations of gene regulation revealed that nutrients could modulate gene expression, an example being the discovery of metal-regulated gene transcription (11, 19, 44). Only more recently have we focused on the ability of non-nutritional botanicals or functional food components to affect gene expression at the transcriptional level. Significant findings include the discovery that hyperforin is an active ingredient of the herbal remedy St. John's wort, and activates gene transcription of cytochrome p450-3A4, causing significant botanical-drug interactions. Recently, the lipid-regulating peroxisome proliferator-activated receptors have been studied as receptors activated by soy isoflavones, perhaps explaining the lipid-lowering effect of soy intake. Epigallocatechin gallate has been shown to be an inhibitor of the protealytic activity of the proteasome; this inhibition has a significant implication for cell proliferation and the stability of transcription factors in the nucleus. Very recently, the effects of botanicals have been studied as activators of sirtuins, important deacetylation enzymes that have been shown to enhance lifespan in a variety of organisms. Sirtuins have been implicated in the lifespan-enhancing effect of caloric restriction. Originally presumed to act mainly on compaction or accessibility of DNA, recent evidence shows important activity of sirtuins as controllers of transcriptional coactivator availability. This review focuses on novel mechanisms by which botanical products regulate cell function via gene transcription. Investigating these newly appreciated mechanisms will assist with the characterization and clarification of specific effects of botanicals on gene expression. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556
      2Department of Animal Science, Food & Nutrition, Southern Illinois University, Carbondale, Illinois 62901
    • ISSN:
      0199-9885
    • Accession Number:
      10.1146/annurev.nutr.25.050304.092639
    • Accession Number:
      17647346
  • Citations
    • ABNT:
      SHAY, N. F.; BANZ, W. J. REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms. Annual Review of Nutrition, [s. l.], v. 25, n. 1, p. 297–315, 2005. Disponível em: . Acesso em: 20 nov. 2019.
    • AMA:
      Shay NF, Banz WJ. REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms. Annual Review of Nutrition. 2005;25(1):297-315. doi:10.1146/annurev.nutr.25.050304.092639.
    • APA:
      Shay, N. F., & Banz, W. J. (2005). REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms. Annual Review of Nutrition, 25(1), 297–315. https://doi.org/10.1146/annurev.nutr.25.050304.092639
    • Chicago/Turabian: Author-Date:
      Shay, Neil F., and William J. Banz. 2005. “REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms.” Annual Review of Nutrition 25 (1): 297–315. doi:10.1146/annurev.nutr.25.050304.092639.
    • Harvard:
      Shay, N. F. and Banz, W. J. (2005) ‘REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms’, Annual Review of Nutrition, 25(1), pp. 297–315. doi: 10.1146/annurev.nutr.25.050304.092639.
    • Harvard: Australian:
      Shay, NF & Banz, WJ 2005, ‘REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms’, Annual Review of Nutrition, vol. 25, no. 1, pp. 297–315, viewed 20 November 2019, .
    • MLA:
      Shay, Neil F., and William J. Banz. “REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms.” Annual Review of Nutrition, vol. 25, no. 1, Aug. 2005, pp. 297–315. EBSCOhost, doi:10.1146/annurev.nutr.25.050304.092639.
    • Chicago/Turabian: Humanities:
      Shay, Neil F., and William J. Banz. “REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms.” Annual Review of Nutrition 25, no. 1 (August 2005): 297–315. doi:10.1146/annurev.nutr.25.050304.092639.
    • Vancouver/ICMJE:
      Shay NF, Banz WJ. REGULATION OF GENE TRANSCRIPTION BY BOTANICALS: Novel Regulatory Mechanisms. Annual Review of Nutrition [Internet]. 2005 Aug [cited 2019 Nov 20];25(1):297–315. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=17647346&authtype=sso&custid=s5834912