OXIDIZED LDL AND LIPIDS AS RISK FACTORS FOR ISCHEMIC HEART DISEASE IN TYPE 2 DIABETES.

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  • Additional Information
    • Alternate Title:
      Oksidovani LDL i lipidi kao faktori rizika za ishemijsku bolest srca kod obolelih od Diabetes mellitusa tip 2.
      Oksidovani LDL i lipidi kao faktori rizika za ishemijsku bolest srca kod obolelih od Diabetes mellitusa tip 2.
    • Author-Supplied Keywords:
      cholesterol
      coronary disease
      diabetes mellitus
      lipids
      lipoproteins, LDL cholesterol
      oxidative stress
      risk factors
      type 2
      dijabetes mellitus
      faktori rizika
      holesterol
      insulin nezavisni
      koronarna bolest
      lipidi
      lipoproteini, LDL holesterol
      stres, oksidativni
      Language of Keywords: English; Serbian
    • Abstract:
      Background. Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). Factors that contribute to endothelial cell dysfunction associated with the initiation of atherosclerosis include oxidative stress. The aim of this study was to investigate the relationship between lipid profile and oxidative stress in type 2 diabetics with and without ischemic heart disease (IHD). Methods. We studied 80 patients with T2D, 40 with IHD (group A1) and 40 without IHD (group A2). We also studied 51 non-diabetics, 31 with IHD (group B1), and 20 without IHD (group B2 -- control group). Lipid profile was estimated by the total cholesterol, HDL cholesterol, LDL cholesterol, the level of triglyceride (Tg), lipoproteina a (Lp a), Apo A I, A II, B 100 and E. To evaluate the oxidative status we measured circulating oxidized LDL (ox LDL), erythrocyte antioxidative enzyme activity: superoxide dismutase (E-SOD), glutathione peroxidase (E-GPX), as well as the total antioxidative serum activity (TAS). Inflammatory reaction was estimated by C-reactive protein (CRP) and fibrinogen. Results. No significant difference was found in the lipid profile in groups A1, A2 and B1, but the group B2 had the lowest one. Lp a level was significantly higher in group B1 comparing to other groups (p < 0.05). There was no significant difference in the level of ox LDL between the groups. In diabetics, ox LDL positively correlated with the total cholesterol, LDL cholesterol, non HDL cholesterol, Apo B 100 and the relations between LDL/HDL and Tg/HDL (p < 0.001), as well as with Tg and fibrinogen (p < 0.05). In group B1, ox LDL positively correlated with total cholesterol, Tg (p < 0.01), LDL, and non HDL cholesterol (p < 0.05) and significantly with Apo B 100 (p < 0.001). There was no significant difference in the antioxidant enzyme activities between the groups of diabetics (A1 and A2), but fibrinogen was higher in the group with IHD (group A1, p < 0.05). Group B1 had lower ESOD activity than the groups A1 and A2 (p < 0.05), but CRP was higher (p < 0.05). There were no significant correlations between oxLDL and CRP in groups A1 and A2, but it was statistically significant in the group B1 (p < 0.05). Conclusion. In this study we demonstrated the increased oxidative stress in diabetics compared to non-diabetics regardless of the presence of IHD. Fibrinogen, but not CRP, was higher in diabetics with IHD, compared to diabetics without IHD. The increased oxidative stress, the reduced antioxidative activity E-SOD, and the higher level of CRP were found in non-diabetics with IHD compared to non-diabetics without IHD. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Uvod. Poremećaj lipidnog statusa u krvi značajan je faktor rizika koji dovodi do arteriosklerotičnih promena na velikim krvnim sudovima kod bolesnika sa dijabetes melitusom tip 2 (T2D). Faktori koji doprinose disfunkciji endotelnih ćelija koje doprinose nastanku arterioskleroze uključuju i oksidativni stres. Cilj istraživanja bio je da se analizuje odnos lipida i oksidativnog stresa kod bolesnika sa T2D, kao i da se uporedi taj odnos između obolelih od dijabetesa sa ishemijskom bolesti srca (IBS) i bez nje. Metode. Ispitivanje je izvršeno kod 80 bolesnika sa T2D: kod 40 bolesnika sa IBS i kod 40 bez IBS (grupe A1 i A2) i kod 51 bolesnika sa IBS bez dijabetesa (grupa B1 - 31 bolesnik) i kod 20 zdravih osoba (grupa B2). Mereni su trigliceridi (Tg), ukupni i HDL holesterol, lipoprotein a (Lp a) i apoprotein A I, A II, B 100 i E, a vrednost LDL holesterola je izračunavana. Za određivanje oksidativnog stresa mereni su oksidovani LDL (oxLDL), aktivnosti eritrocitnih enzima: superoksid dizmutaze i glutation peroksidaze (E-SOD i E-GPx), ukupna antoksidansna aktivnost seruma (TAS), kao i C-reaktivni protein (CRP) i fibrinogen kao markeri inflamacije. Rezultati. Vrednosti lipida se nisu razlikovale u grupama A1, A2 i B1, ali su bile više u odnosu na kontrolnu grupu. Grupa B1 je imala viši Lp a u odnosu na ostale grupe (p < 0,05). OxLDL je u grupama A1, A2 i B1 bio je sličan, ali viši nego kod zdravih. Kod dijabetičara oxLDL je bio u korelaciji sa ukupnim, LDL i non HDL holesterolom, apo B 100, kao i sa odnosima LDL/HDL, Tg/HDL (p < 0,001), Tg i fibrinogenom (p < 0,05). U grupi B1 oxLDL je bio u korelaciji sa ukupnim holesterolom, Tg (p < 0,01), LDL i non HDL holesterolom (p < 0,05) i sa apo B100 (p < 0,001). Nije bilo razlike u antioksidativnoj aktivnosti u grupama A1 i A2, kao ni u nivou CRP, ali je fibrinogen bio viši u grupi A1 (p < 0,05). U grupi B1 akivnost E-SOD je bila niža (p < 0,05) nego kod obolelih od dijabetesa, dok je CRP bio viši (p < 0,05). Korelacije između oxLDL i CRP kod obolelih od dijabetesa nisu bile značajne, ali jesu u grupi B1 (p < 0,05). Zaključak. Vrednosti lipida su bile slične kod obolelih od dijabetesa sa IBS ili bez njega, a bile su više u odnosu na zdrave, kao i oksidativni stres. Oboleli od dijabetesa sa IBS su imali viši fibrinogen, ali ne i CRP u poređenju sa obolelima od dijabetesa bez IBS. Oni bolesnici koji nemaju dijabetes sa IBS imali su visok nivo oxLDL, sniženu antioksidativnu aktivnost E-SOD i visok nivo CRP. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Klinički centar Srbije, Institut za endokrinologiju, dijabetes i bolesti metabolizma, Centar za lipidska ispitivanja i prevenciju kardiovaskularnih komplikacija u dijabetesu, Beograd
    • ISSN:
      0042-8450
    • Accession Number:
      10.2298/VSP0508529Z
    • Accession Number:
      19323652
  • Citations
    • ABNT:
      ZAMAKLAR, M. et al. Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes. Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, [s. l.], v. 62, n. 7/8, p. 529–536, 2005. Disponível em: . Acesso em: 12 nov. 2019.
    • AMA:
      Zamaklar M, Lalić K, Rajković N, et al. Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes. Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia. 2005;62(7/8):529-536. doi:10.2298/VSP0508529Z.
    • APA:
      Zamaklar, M., Lalić, K., Rajković, N., Trifunović, D., Dragašević, M., Popović, L., … Potpara, T. (2005). Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes. Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, 62(7/8), 529–536. https://doi.org/10.2298/VSP0508529Z
    • Chicago/Turabian: Author-Date:
      Zamaklar, Miroslava, Katarina Lalić, Nataša Rajković, Danijela Trifunović, Mirjana Dragašević, Ljiljana Popović, Danijela Drašković, et al. 2005. “Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes.” Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia 62 (7/8): 529–36. doi:10.2298/VSP0508529Z.
    • Harvard:
      Zamaklar, M. et al. (2005) ‘Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes’, Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, 62(7/8), pp. 529–536. doi: 10.2298/VSP0508529Z.
    • Harvard: Australian:
      Zamaklar, M, Lalić, K, Rajković, N, Trifunović, D, Dragašević, M, Popović, L, Drašković, D, Laić, N, Jotić, A, Vasović, O, Lukić, L, Miličić, T & Potpara, T 2005, ‘Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes’, Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, vol. 62, no. 7/8, pp. 529–536, viewed 12 November 2019, .
    • MLA:
      Zamaklar, Miroslava, et al. “Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes.” Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, vol. 62, no. 7/8, July 2005, pp. 529–536. EBSCOhost, doi:10.2298/VSP0508529Z.
    • Chicago/Turabian: Humanities:
      Zamaklar, Miroslava, Katarina Lalić, Nataša Rajković, Danijela Trifunović, Mirjana Dragašević, Ljiljana Popović, Danijela Drašković, et al. “Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes.” Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia 62, no. 7/8 (July 2005): 529–36. doi:10.2298/VSP0508529Z.
    • Vancouver/ICMJE:
      Zamaklar M, Lalić K, Rajković N, Trifunović D, Dragašević M, Popović L, et al. Oxidized Ldl and Lipids as Risk Factors for Ischemic Heart Disease in Type 2 Diabetes. Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia [Internet]. 2005 Jul [cited 2019 Nov 12];62(7/8):529–36. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=19323652&authtype=sso&custid=s5834912