The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      birthweight
      infant mortality
      IUGR
      neonatal mortality
      preterm
    • Abstract:
      Background Our objectives were to examine the associations of neonatal and infant mortality with preterm birth and intrauterine growth restriction ( IUGR), and to estimate the partial population attributable risk per cent ( pPAR%) of neonatal and infant mortality due to preterm birth and IUGR. Methods Participants were HIV-negative pregnant women and their infants enrolled in Dar es Salaam, Tanzania. Gestational age calculated from date of last menstrual period was used to define preterm, and small for gestational age ( SGA) was used as proxy for IUGR. Survival of infants was ascertained at monthly follow-up visits. Cox proportional hazard models were used to estimate the associations of preterm and SGA with neonatal and infant mortality. Results Study included 7225 singletons, of whom 15% were preterm and 21% were SGA; majority of preterm or SGA babies had birthweight ≥2500 g. Compared to term and appropriately sized babies ( AGA), relative risks ( RR) of neonatal mortality among preterm- AGA was 2.6 [95% CI 1.8, 3.9], RR among term- SGA was 2.3 [95% CI 1.6, 3.3], and the highest risk was among the preterm- SGA babies ( RR 15.1 [95% CI 8.2, 27.7]). Risk associated with preterm was elevated throughout the infancy, and risk associated with SGA was elevated during the neonatal period only. The pPAR% of neonatal mortality for preterm was 22% [95% CI 17%, 26%] and for SGA it was 26% [95% CI 16%, 36%]. Conclusions Preterm and SGA birth substantially increased the risk of mortality. Interventions for prevention and management of these conditions are likely to reduce of infant mortality in Tanzania. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Epidemiology, Harvard School of Public Health, Boston MA
      2Department of Biostatistics, Harvard School of Public Health, Boston MA
      3The Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston MA
      4Department of Nutrition, Harvard School of Public Health, Boston MA
      5Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam Tanzania
      6Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam Tanzania
      7Department of Global Health and Population, Harvard School of Public Health, Boston MA
    • ISSN:
      0269-5022
    • Accession Number:
      10.1111/ppe.12085
    • Accession Number:
      92764996
  • Citations
    • ABNT:
      SANIA, A. et al. The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania. Paediatric & Perinatal Epidemiology, [s. l.], v. 28, n. 1, p. 23–31, 2014. DOI 10.1111/ppe.12085. Disponível em: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=92764996&authtype=sso&custid=s5834912. Acesso em: 19 jan. 2020.
    • AMA:
      Sania A, Spiegelman D, Rich EJ, et al. The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania. Paediatric & Perinatal Epidemiology. 2014;28(1):23-31. doi:10.1111/ppe.12085.
    • APA:
      Sania, A., Spiegelman, D., Rich, E. J., Okuma, J., Kisenge, R., Msamanga, G., … Fawzi, W. W. (2014). The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania. Paediatric & Perinatal Epidemiology, 28(1), 23–31. https://doi.org/10.1111/ppe.12085
    • Chicago/Turabian: Author-Date:
      Sania, Ayesha, Donna Spiegelman, Edwards, Janet Rich, James Okuma, Rodrick Kisenge, Gernard Msamanga, Willy Urassa, and Wafaie W. Fawzi. 2014. “The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania.” Paediatric & Perinatal Epidemiology 28 (1): 23–31. doi:10.1111/ppe.12085.
    • Harvard:
      Sania, A. et al. (2014) ‘The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania’, Paediatric & Perinatal Epidemiology, 28(1), pp. 23–31. doi: 10.1111/ppe.12085.
    • Harvard: Australian:
      Sania, A, Spiegelman, D, Rich, EJ, Okuma, J, Kisenge, R, Msamanga, G, Urassa, W & Fawzi, WW 2014, ‘The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania’, Paediatric & Perinatal Epidemiology, vol. 28, no. 1, pp. 23–31, viewed 19 January 2020, .
    • MLA:
      Sania, Ayesha, et al. “The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania.” Paediatric & Perinatal Epidemiology, vol. 28, no. 1, Jan. 2014, pp. 23–31. EBSCOhost, doi:10.1111/ppe.12085.
    • Chicago/Turabian: Humanities:
      Sania, Ayesha, Donna Spiegelman, Edwards, Janet Rich, James Okuma, Rodrick Kisenge, Gernard Msamanga, Willy Urassa, and Wafaie W. Fawzi. “The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania.” Paediatric & Perinatal Epidemiology 28, no. 1 (January 2014): 23–31. doi:10.1111/ppe.12085.
    • Vancouver/ICMJE:
      Sania A, Spiegelman D, Rich EJ, Okuma J, Kisenge R, Msamanga G, et al. The Contribution of Preterm Birth and Intrauterine Growth Restriction to Infant Mortality in Tanzania. Paediatric & Perinatal Epidemiology [Internet]. 2014 Jan [cited 2020 Jan 19];28(1):23–31. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=92764996&authtype=sso&custid=s5834912