The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English)

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  • Additional Information
    • Publication Year:
      2014
    • Author-Supplied Keywords:
      Genotype
      IFN-γ
      IL-18
      Malaria
      Parasite Reservoir
    • Abstract:
      Background & Objective: In human malaria, genotype of cytokines affect immune system. The impact of genotype - 137G/C in IL-18 and +874A/T in IFN-γ on the severity of malaria and the quality of treatment -- as factors to form asymptomatic persons in endemic regions- has been investigated. Materials & Methods: 100 patients and 102 healthy persons were evaluated by Nested-PCR and thick blood film. IL- 18(G-137C) and IFN-γ (A+874T) were determined by Single Specific Primer-Polymerase Chain Reaction and ARMSPCR methods, respectively. The results were analyzed statistically. Results: In this research, it has been observed that allele-T in IFN-γ gene and allele-C in IL-8 gene have protective effects against severity of Malaria. In addition, it has clearly been found that development and growth rate of plasmodium in μl of blood as well as anemia induced malaria significantly reduced in carriers of these alleles (p<0.0001). This effect has also been observed in the quality of the treatment in such a way that no parasite remained at the end of second day of treatment in carriers of alleles IFN-γTT and IL-18CC. Conclusion: These findings issue the impact of immunogenetypes of patients on treatment quality and asymptomatic patients and parasite reservoir as effective factors in endemic malaria. Immunogenetypes of people may play as a remarkable factor to control malaria in endemic areas. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa is the property of Journal of Fasa University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      22285105
    • Accession Number:
      100262082
  • Citations
    • ABNT:
      AMERI, G. R. et al. The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English). Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa, [s. l.], v. 4, n. 3, p. 284, 2014. Disponível em: . Acesso em: 24 ago. 2019.
    • AMA:
      Ameri GR, Malekzadeh K, Noor-Mohamadi Z, Shekari M, Turki H, Solaimani H. The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English). Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa. 2014;4(3):284. http://ezproxy.parker.edu/login?url={targeturl}. Accessed August 24, 2019.
    • APA:
      Ameri, G. R., Malekzadeh, K., Noor-Mohamadi, Z., Shekari, M., Turki, H., & Solaimani, H. (2014). The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English). Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa, 4(3), 284. Retrieved from http://ezproxy.parker.edu/login?url={targeturl}
    • Chicago/Turabian: Author-Date:
      Ameri, G. R., K. Malekzadeh, Z. Noor-Mohamadi, M. Shekari, H. Turki, and H. Solaimani. 2014. “The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English).” Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa 4 (3): 284. http://ezproxy.parker.edu/login?url={targeturl}.
    • Harvard:
      Ameri, G. R. et al. (2014) ‘The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English)’, Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa, 4(3), p. 284. Available at: http://ezproxy.parker.edu/login?url={targeturl} (Accessed: 24 August 2019).
    • Harvard: Australian:
      Ameri, GR, Malekzadeh, K, Noor-Mohamadi, Z, Shekari, M, Turki, H & Solaimani, H 2014, ‘The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English)’, Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa, vol. 4, no. 3, p. 284, viewed 24 August 2019, .
    • MLA:
      Ameri, G. R., et al. “The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English).” Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa, vol. 4, no. 3, Sept. 2014, p. 284. EBSCOhost, ezproxy.parker.edu/login?url={targeturl}.
    • Chicago/Turabian: Humanities:
      Ameri, G. R., K. Malekzadeh, Z. Noor-Mohamadi, M. Shekari, H. Turki, and H. Solaimani. “The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English).” Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa 4, no. 3 (September 2014): 284. http://ezproxy.parker.edu/login?url={targeturl}.
    • Vancouver/ICMJE:
      Ameri GR, Malekzadeh K, Noor-Mohamadi Z, Shekari M, Turki H, Solaimani H. The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment. (English). Journal of Fasa University of Medical Sciences / Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa [Internet]. 2014 Sep [cited 2019 Aug 24];4(3):284. Available from: http://ezproxy.parker.edu/login?url={targeturl}