Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy.

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  • Additional Information
    • Publication Year:
      2016
    • Author-Supplied Keywords:
      Amniotes
      Anatomy
      Animal cells
      Animals
      Astrocytes
      Biology and life sciences
      Blood cells
      Cell biology
      Cellular types
      Diagnostic medicine
      Eyes
      Glial cells
      Head
      Immune cells
      Immune response
      Immunology
      Inflammation
      Ischemia
      Macroglial cells
      Macrophages
      Mammals
      Medicine and health sciences
      Ocular anatomy
      Ocular system
      Optic nerve
      Organisms
      Pathology and laboratory medicine
      Primates
      Research Article
      Retina
      Signs and symptoms
      Vascular medicine
      Vertebrates
      White blood cells
    • Abstract:
      Introduction: Polyamidoamine dendrimer nanoparticles (~ 4 nanometers) are inert polymers that can be linked to biologically active compounds. These dendrimers selectively target and accumulate in inflammatory cells upon systemic administration. Dendrimer-linked compounds enable sustained release of therapeutic compounds directly at the site of damage. The purpose of this study was to determine if dendrimers can be used to target the optic nerve (ON) ischemic lesion in our rodent and nonhuman primate models of nonarteritic anterior ischemic optic neuropathy (NAION), a disease affecting >10,000 individuals in the US annually, and for which there currently is no effective treatment. Methods: NAION was induced in male Long-Evans rats (rNAION) and in one adult male rhesus monkey (pNAION) using previously described procedures. Dendrimers were covalently linked to near-infrared cyanine-5 fluorescent dye (D-Cy5) and injected both intravitreally and systemically (in the rats) or just systemically (in the monkey) to evaluate D-Cy5 tissue accumulation in the eye and optic nerve following induction of NAION. Results: Following NAION induction, Cy-5 dendrimers selectively accumulated in astrocytes and circulating macrophages. Systemic dendrimer administration provided the best penetration of the ON lesion site when injected shortly after induction. Systemic administration 1 day post-induction in the pNAION model gave localization similar to that seen in the rats. Conclusions: Dendrimers selectively target the ischemic ON lesion after induction of both rNAION and pNAION. Systemic nanoparticle-linked therapeutics thus may provide a powerful, targeted and safe approach to NAION treatment by providing sustained and focused treatment of the cells directly affected by ischemia. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      19326203
    • Accession Number:
      114992332
  • Citations
    • ABNT:
      GUO, Y. et al. Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. PLoS ONE, [s. l.], v. 11, n. 4, p. 1, 2016. Disponível em: . Acesso em: 24 ago. 2019.
    • AMA:
      Guo Y, Johnson MA, Mehrabian Z, et al. Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. PLoS ONE. 2016;11(4):1. http://ezproxy.parker.edu/login?url={targeturl}. Accessed August 24, 2019.
    • APA:
      Guo, Y., Johnson, M. A., Mehrabian, Z., Mishra, M. K., Kannan, R., Miller, N. R., & Bernstein, S. L. (2016). Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. PLoS ONE, 11(4), 1. Retrieved from http://ezproxy.parker.edu/login?url={targeturl}
    • Chicago/Turabian: Author-Date:
      Guo, Yan, Mary A. Johnson, Zara Mehrabian, Manoj K. Mishra, Rangaramanujam Kannan, Neil R. Miller, and Steven L. Bernstein. 2016. “Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy.” PLoS ONE 11 (4): 1. http://ezproxy.parker.edu/login?url={targeturl}.
    • Harvard:
      Guo, Y. et al. (2016) ‘Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy’, PLoS ONE, 11(4), p. 1. Available at: http://ezproxy.parker.edu/login?url={targeturl} (Accessed: 24 August 2019).
    • Harvard: Australian:
      Guo, Y, Johnson, MA, Mehrabian, Z, Mishra, MK, Kannan, R, Miller, NR & Bernstein, SL 2016, ‘Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy’, PLoS ONE, vol. 11, no. 4, p. 1, viewed 24 August 2019, .
    • MLA:
      Guo, Yan, et al. “Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy.” PLoS ONE, vol. 11, no. 4, Apr. 2016, p. 1. EBSCOhost, ezproxy.parker.edu/login?url={targeturl}.
    • Chicago/Turabian: Humanities:
      Guo, Yan, Mary A. Johnson, Zara Mehrabian, Manoj K. Mishra, Rangaramanujam Kannan, Neil R. Miller, and Steven L. Bernstein. “Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy.” PLoS ONE 11, no. 4 (April 29, 2016): 1. http://ezproxy.parker.edu/login?url={targeturl}.
    • Vancouver/ICMJE:
      Guo Y, Johnson MA, Mehrabian Z, Mishra MK, Kannan R, Miller NR, et al. Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. PLoS ONE [Internet]. 2016 Apr 29 [cited 2019 Aug 24];11(4):1. Available from: http://ezproxy.parker.edu/login?url={targeturl}