Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.

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  • Additional Information
    • Publication Year:
      2017
    • Subject Terms:
    • Author-Supplied Keywords:
      Fetal Alcohol Syndrome
      Functional Magnetic Resonance Imaging
      Go/NoGo
      Prenatal Alcohol Exposure
      Response Inhibition
    • NAICS/Industry Codes:
      NAICS/Industry Codes 621512 Diagnostic Imaging Centers
      325120 Industrial Gas Manufacturing
    • Abstract:
      Background Response inhibition is a distinct aspect of executive function that is frequently impaired in children with fetal alcohol spectrum disorders ( FASD). We used a Go/NoGo ( GNG) task in a functional MRI protocol to investigate differential activation of brain regions in the response inhibition network in children diagnosed with full or partial fetal alcohol syndrome ( FAS/ PFAS), compared with healthy controls. Methods A rapid, event-related task with 120 Go and 60 NoGo trials was used to study children aged 8 to 12 years-8 with FAS/ PFAS, 17 controls. Letters were projected sequentially, with Go and NoGo trials randomly interspersed across the task. BOLD signal in the whole brain was contrasted for the correct NoGo minus correct Go trials between the FAS/ PFAS and control groups. Results Compared to the FAS/ PFAS group, controls showed greater activation of the inferior frontal and anterior cingulate network linked to response inhibition in typically developing children. By contrast, the FAS/ PFAS group showed greater BOLD response in dorsolateral prefrontal cortex and other middle prefrontal regions, suggesting compensation for inefficient function of pathways that normally mediate inhibitory processing. All group differences were significant after control for potential confounding variables. None of the effects of prenatal alcohol exposure on activation of the regions associated with response inhibition were attributable to the effects of this exposure on IQ. Conclusions This is the first FASD GNG study in which all participants in the exposed group met criteria for a diagnosis of full FAS or PFAS. Although FASD is frequently comorbid with attention deficit hyperactivity disorder, the pattern of brain activation seen in these disorders differs, suggesting that different neural pathways mediate response inhibition in FASD and that different interventions for FASD are, therefore, warranted. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Alcoholism: Clinical & Experimental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      01456008
    • Accession Number:
      121000971
  • Citations
    • ABNT:
      KODALI, V. N. et al. Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol. Alcoholism: Clinical & Experimental Research, [s. l.], v. 41, n. 2, p. 334, 2017. Disponível em: . Acesso em: 16 set. 2019.
    • AMA:
      Kodali VN, Jacobson JL, Lindinger NM, et al. Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol. Alcoholism: Clinical & Experimental Research. 2017;41(2):334. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912. Accessed September 16, 2019.
    • APA:
      Kodali, V. N., Jacobson, J. L., Lindinger, N. M., Dodge, N. C., Molteno, C. D., Meintjes, E. M., & Jacobson, S. W. (2017). Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol. Alcoholism: Clinical & Experimental Research, 41(2), 334. Retrieved from http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912
    • Chicago/Turabian: Author-Date:
      Kodali, Vikas N., Joseph L. Jacobson, Nadine M. Lindinger, Neil C. Dodge, Christopher D. Molteno, Ernesta M. Meintjes, and Sandra W. Jacobson. 2017. “Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.” Alcoholism: Clinical & Experimental Research 41 (2): 334. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912.
    • Harvard:
      Kodali, V. N. et al. (2017) ‘Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol’, Alcoholism: Clinical & Experimental Research, 41(2), p. 334. Available at: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912 (Accessed: 16 September 2019).
    • Harvard: Australian:
      Kodali, VN, Jacobson, JL, Lindinger, NM, Dodge, NC, Molteno, CD, Meintjes, EM & Jacobson, SW 2017, ‘Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol’, Alcoholism: Clinical & Experimental Research, vol. 41, no. 2, p. 334, viewed 16 September 2019, .
    • MLA:
      Kodali, Vikas N., et al. “Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.” Alcoholism: Clinical & Experimental Research, vol. 41, no. 2, Feb. 2017, p. 334. EBSCOhost, widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912.
    • Chicago/Turabian: Humanities:
      Kodali, Vikas N., Joseph L. Jacobson, Nadine M. Lindinger, Neil C. Dodge, Christopher D. Molteno, Ernesta M. Meintjes, and Sandra W. Jacobson. “Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.” Alcoholism: Clinical & Experimental Research 41, no. 2 (February 2017): 334. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912.
    • Vancouver/ICMJE:
      Kodali VN, Jacobson JL, Lindinger NM, Dodge NC, Molteno CD, Meintjes EM, et al. Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol. Alcoholism: Clinical & Experimental Research [Internet]. 2017 Feb [cited 2019 Sep 16];41(2):334. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=121000971&authtype=sso&custid=s5834912