Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium.

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  • Additional Information
    • Publication Year:
      2019
    • Author-Supplied Keywords:
      Animal genomics
      Animals
      Bioinformatics
      Biology and life sciences
      Comparative genomics
      Computational biology
      Database and informatics methods
      Eukaryota
      Genetics
      Genome analysis
      Genomic libraries
      Genomics
      Helminths
      Invertebrate genomics
      Invertebrates
      Mammalian genomics
      Organisms
      Research and analysis methods
      Research Article
      Schistosoma
      Schistosoma haematobium
      Schistosoma mansoni
      Sequence alignment
      Sequence analysis
    • NAICS/Industry Codes:
      NAICS/Industry Codes 541940 Veterinary Services
    • Abstract:
      Intestinal infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the human parasite S. haematobium with natural hybridisation observed in West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between species may dramatically influence disease dynamics and parasite evolution. We have generated a 374 Mb assembly of the S. bovis genome using Illumina and PacBio-based technologies. Despite infecting different hosts and organs, the genome sequences of S. bovis and S. haematobium appeared strikingly similar with 97% sequence identity. The two species share 98% of protein-coding genes, with an average sequence identity of 97.3% at the amino acid level. Genome comparison identified large continuous parts of the genome (up to several 100 kb) showing almost 100% sequence identity between S. bovis and S. haematobium. It is unlikely that this is a result of genome conservation and provides further evidence of natural interspecific hybridization between S. bovis and S. haematobium. Our results suggest that foreign DNA obtained by interspecific hybridization was maintained in the population through multiple meiosis cycles and that hybrids were sexually reproductive, producing viable offspring. The S. bovis genome assembly forms a highly valuable resource for studying schistosome evolution and exploring genetic regions that are associated with species-specific phenotypic traits. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      15537366
    • Accession Number:
      134242552
  • Citations
    • ABNT:
      OEY, H. et al. Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium. PLoS Pathogens, [s. l.], v. 15, n. 1, p. 1, 2019. Disponível em: . Acesso em: 24 ago. 2019.
    • AMA:
      Oey H, Zakrzewski M, Gravermann K, et al. Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium. PLoS Pathogens. 2019;15(1):1. http://ezproxy.parker.edu/login?url={targeturl}. Accessed August 24, 2019.
    • APA:
      Oey, H., Zakrzewski, M., Gravermann, K., Young, N. D., Korhonen, P. K., Gobert, G. N., … McManus, D. P. (2019). Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium. PLoS Pathogens, 15(1), 1. Retrieved from http://ezproxy.parker.edu/login?url={targeturl}
    • Chicago/Turabian: Author-Date:
      Oey, Harald, Martha Zakrzewski, Kerstin Gravermann, Neil D. Young, Pasi K. Korhonen, Geoffrey N. Gobert, Sujeevi Nawaratna, et al. 2019. “Whole-Genome Sequence of the Bovine Blood Fluke Schistosoma Bovis Supports Interspecific Hybridization with S. Haematobium.” PLoS Pathogens 15 (1): 1. http://ezproxy.parker.edu/login?url={targeturl}.
    • Harvard:
      Oey, H. et al. (2019) ‘Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium’, PLoS Pathogens, 15(1), p. 1. Available at: http://ezproxy.parker.edu/login?url={targeturl} (Accessed: 24 August 2019).
    • Harvard: Australian:
      Oey, H, Zakrzewski, M, Gravermann, K, Young, ND, Korhonen, PK, Gobert, GN, Nawaratna, S, Hasan, S, Martínez, DM, You, H, Lavin, M, Jones, MK, Ragan, MA, Stoye, J, Oleaga, A, Emery, AM, Webster, B, Rollinson, D, Gasser, RB & McManus, DP 2019, ‘Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium’, PLoS Pathogens, vol. 15, no. 1, p. 1, viewed 24 August 2019, .
    • MLA:
      Oey, Harald, et al. “Whole-Genome Sequence of the Bovine Blood Fluke Schistosoma Bovis Supports Interspecific Hybridization with S. Haematobium.” PLoS Pathogens, vol. 15, no. 1, Jan. 2019, p. 1. EBSCOhost, ezproxy.parker.edu/login?url={targeturl}.
    • Chicago/Turabian: Humanities:
      Oey, Harald, Martha Zakrzewski, Kerstin Gravermann, Neil D. Young, Pasi K. Korhonen, Geoffrey N. Gobert, Sujeevi Nawaratna, et al. “Whole-Genome Sequence of the Bovine Blood Fluke Schistosoma Bovis Supports Interspecific Hybridization with S. Haematobium.” PLoS Pathogens 15, no. 1 (January 23, 2019): 1. http://ezproxy.parker.edu/login?url={targeturl}.
    • Vancouver/ICMJE:
      Oey H, Zakrzewski M, Gravermann K, Young ND, Korhonen PK, Gobert GN, et al. Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium. PLoS Pathogens [Internet]. 2019 Jan 23 [cited 2019 Aug 24];15(1):1. Available from: http://ezproxy.parker.edu/login?url={targeturl}