Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385.

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  • Additional Information
    • Publication Year:
      2013
    • Author-Supplied Keywords:
      A antagonist
      Crystal structure
      Spectroscopic analysis
      Synthesis
      ZM 241385
    • Abstract:
      Herein, we describe the synthesis of the adenosine A antagonist ZM 241385 ( 9) starting from commercially available 2-furanhydrazide ( 1) and including a comprehensive structural characterization of all the intermediates and the final product. In addition, extensive NMR analysis, including temperature and concentration-dependent experiments, are reported as well as the first single-crystal structure of the compound ZM 241385 ( 9) as the trihydrate. Furthermore, an extensive structural comparison of the single-crystal structure with the published protein bound X-ray structures is reported. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Structural Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      10400400
    • Accession Number:
      89046609
  • Citations
    • ABNT:
      JÖRG, M. et al. Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385. Structural Chemistry, [s. l.], v. 24, n. 4, p. 1241, 2013. Disponível em: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912. Acesso em: 16 dez. 2019.
    • AMA:
      Jörg M, Agostino M, Yuriev E, et al. Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385. Structural Chemistry. 2013;24(4):1241. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912. Accessed December 16, 2019.
    • APA:
      Jörg, M., Agostino, M., Yuriev, E., Mak, F., Miller, N., White, J., … Capuano, B. (2013). Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385. Structural Chemistry, 24(4), 1241. Retrieved from http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912
    • Chicago/Turabian: Author-Date:
      Jörg, Manuela, Mark Agostino, Elizabeth Yuriev, Frankie Mak, Neil Miller, Jonathan White, Peter Scammells, and Ben Capuano. 2013. “Synthesis, Molecular Structure, NMR Spectroscopic and Computational Analysis of a Selective Adenosine A Antagonist, ZM 241385.” Structural Chemistry 24 (4): 1241. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912.
    • Harvard:
      Jörg, M. et al. (2013) ‘Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385’, Structural Chemistry, 24(4), p. 1241. Available at: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912 (Accessed: 16 December 2019).
    • Harvard: Australian:
      Jörg, M, Agostino, M, Yuriev, E, Mak, F, Miller, N, White, J, Scammells, P & Capuano, B 2013, ‘Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385’, Structural Chemistry, vol. 24, no. 4, p. 1241, viewed 16 December 2019, .
    • MLA:
      Jörg, Manuela, et al. “Synthesis, Molecular Structure, NMR Spectroscopic and Computational Analysis of a Selective Adenosine A Antagonist, ZM 241385.” Structural Chemistry, vol. 24, no. 4, Aug. 2013, p. 1241. EBSCOhost, widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912.
    • Chicago/Turabian: Humanities:
      Jörg, Manuela, Mark Agostino, Elizabeth Yuriev, Frankie Mak, Neil Miller, Jonathan White, Peter Scammells, and Ben Capuano. “Synthesis, Molecular Structure, NMR Spectroscopic and Computational Analysis of a Selective Adenosine A Antagonist, ZM 241385.” Structural Chemistry 24, no. 4 (August 2013): 1241. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912.
    • Vancouver/ICMJE:
      Jörg M, Agostino M, Yuriev E, Mak F, Miller N, White J, et al. Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A antagonist, ZM 241385. Structural Chemistry [Internet]. 2013 Aug [cited 2019 Dec 16];24(4):1241. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=89046609&authtype=sso&custid=s5834912