Bruschettini, Matteo 1; Zappettini, Simona 2; Ramenghi, Luca Antonio 3; Calevo, Maria Grazia 4
- Review Group Information:
Cochrane Database of Systematic Reviews. This document is a Academic Journal
Review first published in Issue 2, 2016.
Protocol first published in Issue 1, 2015.
This version first published online: 13 February 2016 in Issue 2, 2016.
- Update Information:
Publication Status: New in Issue 2, 2016
Most recent changes:
Information not supplied by reviewer.
Matteo Bruschettini 1; firstname.lastname@example.org
1Institute for Clinical Sciences, Lund University, Department of Pediatrics, Lund, Sweden, 21185
2Health Regional Agency of the Liguria Region, Genoa, Italy,
3Istituto Giannina Gaslini, Neonatal Intensive Care Unit, Genoa, Italy,
4Istituto Giannina Gaslini, Epidemiology, Biostatistics and Committees Unit, Genoa, Italy, 16147
- Sources of Support:
Intramural sources of support: No sources of support supplied.
Extramural sources of support: No sources of support supplied.
Background: Carbon dioxide (CO2) measurement is a fundamental evaluation in a neonatal intensive care unit (NICU), as both low and high values of CO2 might have detrimental effects on neonatal morbidity and mortality. Though measurement of CO2 in the arterial blood gas is the most accurate way to assess the amount of CO2, it requires blood sampling and it does not provide a continuous monitoring of CO2. Objectives: To assess whether the use of continuous transcutaneous CO2 (tcCO2) monitoring in newborn infants reduces mortality and improves short and long term respiratory and neurodevelopmental outcomes. Search methods: We used the standard search strategy of the Cochrane Neonatal Review group to search the Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 11), MEDLINE via PubMed (1966 to November 1, 2015), EMBASE (1980 to November 1, 2015), and CINAHL (1982 to November 1, 2015). We also searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles for randomized controlled trials and quasi‐randomized trials. Selection criteria: Randomized, quasi‐randomized and cluster randomized controlled trials comparing different strategies regarding tcCO2 monitoring in newborns. Three comparisons were considered, that is, continuous tcCO2 monitoring versus 1) any intermittent modalities to measure CO2; 2) other continuous CO2 monitoring; and 3) with or without intermittent CO2 monitoring. Data collection and analysis: We used the standard methods of the Cochrane Neonatal Review Group. Two review authors independently assessed studies identified by the search strategy for inclusion. Main results: Our search strategy yielded 106 references. Two review authors independently assessed all references for inclusion. We did not find any completed studies for inclusion, nor ongoing trials. Authors' conclusions: There was no evidence to recommend or refute the use of transcutaneous CO2 monitoring in neonates. Well‐designed, adequately powered randomized controlled studies are necessary to address efficacy and safety of transcutaneous CO2 monitoring in neonates.
Copyright © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
- Medical Subject Headings(MeSH):
Blood Gas Monitoring, Transcutaneous /*methods
This record should be cited as: Bruschettini, Matteo, Zappettini, Simona, Ramenghi, Luca Antonio, Calevo, Maria Grazia. Transcutaneous carbon dioxide monitoring for the prevention of neonatal morbidity and mortality. (Protocol) Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD011494. DOI: 10.1002/14651858.CD011494.pub2.
- Accession Number: