Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants

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    • Additional Information
      • Reviewers:
        Romantsik, Olga 1; Bruschettini, Matteo 1 2; Moreira, Alvaro 3; Thébaud, Bernard 4 5 6; Ley, David 7; Bruschettini, Matteo 1
      • Review Group Information:
      • Source:
        Cochrane Database of Systematic Reviews. This document is a Academic Journal
        Review first published in Issue 9, 2019.
        Protocol first published in Issue 11, 2018.
        This version first published online: 24 September 2019 in Issue 9, 2019.
      • Update Information:
        Publication Status: New in Issue 9, 2019
        Most recent changes:
        Information not supplied by reviewer.
      • Contact:
        Matteo Bruschettini 1; matteo.bruschettini@med.lu.se matbrus@gmail.com
      • Affiliations:
        1Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Paediatrics, Lund, Sweden,
        2Skåne University Hospital, Cochrane Sweden, Wigerthuset, Remissgatan 4, first floor, room 11‐221, Lund, Sweden, 22185
        3University of Texas Health Science Center at San Antonio, Pediatrics, Division of Neonatology, San Antonio, Texas, USA,
        4Children's Hospital of Eastern Ontario, Department of Pediatrics, Ottawa, ON, Canada,
        5Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Ottawa, Canada,
        6University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, Canada,
        7Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Paediatrics, Lund, Sweden,
      • Sources of Support:
        Intramural sources of support: No sources of support supplied.
        Extramural sources of support: No sources of support supplied.
      • Abstract:
        Background: Germinal matrix‐intraventricular haemorrhage (GMH‐IVH) remains a substantial issue in neonatal intensive care units worldwide. Current therapies to prevent or treat GMH‐IVH are limited. Stem cell‐based therapies offer a potential therapeutic approach to repair, restore, and/or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonatal studies. Objectives: To determine the benefits and harms of stem cell‐based interventions for prevention or treatment of germinal matrix‐intraventricular haemorrhage (GM‐IVH) in preterm infants. Search methods: We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 1), in the Cochrane Library; MEDLINE via PubMed (1966 to 7 January 2019); Embase (1980 to 7 January 2019); and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to 7 January 2019). We also searched clinical trials databases, conference proceedings, and reference lists of retrieved articles for randomised controlled trials and quasi‐randomised trials. Selection criteria: We attempted to identify randomised controlled trials, quasi‐randomised controlled trials, and cluster trials comparing (1) stem cell‐based interventions versus control; (2) mesenchymal stromal cells (MSCs) of type or source versus MSCs of other type or source; (3) stem cell‐based interventions other than MSCs of type or source versus stem cell‐based interventions other than MSCs of other type or source; or (4) MSCs versus stem cell‐based interventions other than MSCs. For prevention studies, we included extremely preterm infants (less than 28 weeks' gestation), 24 hours of age or less, without ultrasound diagnosis of GM‐IVH; for treatment studies, we included preterm infants (less than 37 weeks' gestation), of any postnatal age, with ultrasound diagnosis of GM‐IVH. Data collection and analysis: For each of the included trials, two review authors independently planned to extract data (e.g. number of participants, birth weight, gestational age, type and source of MSCs, other stem cell‐based interventions) and assess the risk of bias (e.g. adequacy of randomisation, blinding, completeness of follow‐up). Primary outcomes considered in this review are all‐cause neonatal mortality, major neurodevelopmental disability, GM‐IVH, and extension of pre‐existing non‐severe GM‐IVH. We planned to use the GRADE approach to assess the quality of evidence. Main results: Our search strategy yielded 769 references. We did not find any completed studies for inclusion. One randomised controlled trial is currently registered and ongoing. Five phase 1 trials are described in the excluded studies. Authors' conclusions: Currently no evidence is available to show the benefits or harms of stem cell‐based interventions for treatment or prevention of GM‐IVH in preterm infants.
      • ISSN:
        1465-1858
      • Rights:
        Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
      • Medical Subject Headings(MeSH):
        Infant Mortality*
        Infant, Extremely Premature*
        Stem Cells*
        Cerebral Hemorrhage /*prevention & control
        Cerebrovascular Circulation /*physiology
        Infant, Premature, Diseases /*prevention & control
        Humans
        Infant
        Infant, Newborn
        Infant, Low Birth Weight
        Infant, Premature, Diseases /etiology
        Randomized Controlled Trials as Topic
      • Source:
        This record should be cited as: Romantsik, Olga, Bruschettini, Matteo, Moreira, Alvaro, Thébaud, Bernard, Ley, David, Bruschettini, Matteo. Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants. (Protocol) Cochrane Database of Systematic Reviews 2019, Issue 9. Art. No.: CD013201. DOI: 10.1002/14651858.CD013201.pub2.
      • Accession Number:
        edschh.CD013201
    • Citations
      • ABNT:
        ROMANTSIK, O. Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants. Cochrane Database of Systematic Reviews, [s. l.], n. 9, [s. d.]. Disponível em: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912. Acesso em: 3 dez. 2020.
      • AMA:
        Romantsik O. Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants. Bruschettini M, Moreira A, Thébaud B, Ley D, Bruschettini M, eds. Cochrane Database of Systematic Reviews. (9). Accessed December 3, 2020. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912
      • APA:
        Romantsik, O. (n.d.). Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants. Cochrane Database of Systematic Reviews, 9.
      • Chicago/Turabian: Author-Date:
        Romantsik, Olga. 2020. “Stem Cell‐based Interventions for the Prevention and Treatment of Germinal Matrix‐intraventricular Haemorrhage in Preterm Infants.” Edited by Matteo Bruschettini, Alvaro Moreira, Bernard Thébaud, David Ley, and Matteo Bruschettini. Cochrane Database of Systematic Reviews, no. 9. Accessed December 3. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912.
      • Harvard:
        Romantsik, O. (no date) ‘Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants’, Cochrane Database of Systematic Reviews. Edited by M. Bruschettini et al., (9). Available at: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912 (Accessed: 3 December 2020).
      • Harvard: Australian:
        Romantsik, O n.d., ‘Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants’, in M Bruschettini, A Moreira, B Thébaud, D Ley & M Bruschettini (eds), Cochrane Database of Systematic Reviews, no. 9, viewed 3 December 2020, .
      • MLA:
        Romantsik, Olga. “Stem Cell‐based Interventions for the Prevention and Treatment of Germinal Matrix‐intraventricular Haemorrhage in Preterm Infants.” Cochrane Database of Systematic Reviews, edited by Matteo Bruschettini et al., no. 9. EBSCOhost, widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912. Accessed 3 Dec. 2020.
      • Chicago/Turabian: Humanities:
        Romantsik, Olga. “Stem Cell‐based Interventions for the Prevention and Treatment of Germinal Matrix‐intraventricular Haemorrhage in Preterm Infants.” Edited by Matteo Bruschettini, Alvaro Moreira, Bernard Thébaud, David Ley, and Matteo Bruschettini. Cochrane Database of Systematic Reviews, no. 9. Accessed December 3, 2020. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912.
      • Vancouver/ICMJE:
        Romantsik O. Stem cell‐based interventions for the prevention and treatment of germinal matrix‐intraventricular haemorrhage in preterm infants. Bruschettini M, Moreira A, Thébaud B, Ley D, Bruschettini M, editors. Cochrane Database of Systematic Reviews [Internet]. [cited 2020 Dec 3];(9). Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edschh&AN=edschh.CD013201&authtype=sso&custid=s5834912