Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: American Society for Nutrition Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J. Nutr. Subsets: MEDLINE
    • Publication Information:
      Publication: : Rockville, MD : American Society for Nutrition
      Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas
    • Subject Terms:
    • Abstract:
      Whether neonatal vitamin A supplementation (NVAS) should be policy in areas with vitamin A deficiency is debated. We observed that a smaller dose of vitamin A may decrease mortality more than a larger dose and conducted a randomized, double-blind, placebo-controlled trial in Guinea-Bissau with the primary aim of comparing the effect of 50,000 with 25,000 IU neonatal vitamin A on infant mortality. The secondary aim was to study the effect of NVAS vs. placebo, including a combined analysis of NVAS trials. Between 2004 and 2007, normal-birth-weight neonates were randomly assigned in a 1:1:1 ratio to be administered 2 different doses of vitamin A (50,000 or 25,000 IU) or placebo. Infant mortality rates (MRs) were compared in Cox models providing MR ratios (MRRs). Among 6048 children enrolled, there were 160 deaths in 4125 person-years (MR = 39/1000). There was no difference in mortality between the 2 dosage groups: the MRR for 25,000 vs. 50,000 IU was 0.96 (95% CI: 0.67, 1.38). Neither dose of NVAS was associated with lower mortality than placebo (MRR = 1.28; 95% CI: 0.91, 1.81). In a combined analysis of the present trial and 2 previous NVAS trials in Guinea-Bissau, the effect of receiving NVAS (any dose) vs. placebo was 1.13 (95% CI: 0.94, 1.36) and differed significantly (P = 0.01) between boys (0.80; 95% CI: 0.58, 1.09) and girls (1.35; 95% CI: 1.04, 1.75). We could not confirm that a smaller dose of neonatal vitamin A reduces mortality more than a larger dose. We confirmed 2 other trials in Guinea-Bissau that showed no beneficial effect of NVAS. This trial was registered at clinicaltrials.gov as NCT00168610.
      (© 2014 American Society for Nutrition.)
    • Molecular Sequence:
      ClinicalTrials.gov NCT00168610
    • Accession Number:
      0 (Vitamins)
      11103-57-4 (Vitamin A)
    • Publication Date:
      Date Created: 20140704 Date Completed: 20141215 Latest Revision: 20140821
    • Publication Date:
      20200827
    • Accession Number:
      10.3945/jn.114.192674
    • Accession Number:
      24991044
  • Citations
    • ABNT:
      BENN, C. S. et al. Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial. The Journal of nutrition, [s. l.], v. 144, n. 9, p. 1474–1479, 2014. DOI 10.3945/jn.114.192674. Disponível em: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=24991044&authtype=sso&custid=s5834912. Acesso em: 20 set. 2020.
    • AMA:
      Benn CS, Diness BR, Balde I, et al. Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial. The Journal of nutrition. 2014;144(9):1474-1479. doi:10.3945/jn.114.192674
    • APA:
      Benn, C. S., Diness, B. R., Balde, I., Rodrigues, A., Lausch, K. R., Martins, C. L., Fisker, A. B., & Aaby, P. (2014). Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial. The Journal of Nutrition, 144(9), 1474–1479. https://doi.org/10.3945/jn.114.192674
    • Chicago/Turabian: Author-Date:
      Benn, Christine S, Birgitte R Diness, Ibraima Balde, Amabelia Rodrigues, Karen R Lausch, Cesario L Martins, Ane B Fisker, and Peter Aaby. 2014. “Two Different Doses of Supplemental Vitamin A Did Not Affect Mortality of Normal-Birth-Weight Neonates in Guinea-Bissau in a Randomized Controlled Trial.” The Journal of Nutrition 144 (9): 1474–79. doi:10.3945/jn.114.192674.
    • Harvard:
      Benn, C. S. et al. (2014) ‘Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial’, The Journal of nutrition, 144(9), pp. 1474–1479. doi: 10.3945/jn.114.192674.
    • Harvard: Australian:
      Benn, CS, Diness, BR, Balde, I, Rodrigues, A, Lausch, KR, Martins, CL, Fisker, AB & Aaby, P 2014, ‘Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial’, The Journal of nutrition, vol. 144, no. 9, pp. 1474–1479, viewed 20 September 2020, .
    • MLA:
      Benn, Christine S., et al. “Two Different Doses of Supplemental Vitamin A Did Not Affect Mortality of Normal-Birth-Weight Neonates in Guinea-Bissau in a Randomized Controlled Trial.” The Journal of Nutrition, vol. 144, no. 9, Sept. 2014, pp. 1474–1479. EBSCOhost, doi:10.3945/jn.114.192674.
    • Chicago/Turabian: Humanities:
      Benn, Christine S, Birgitte R Diness, Ibraima Balde, Amabelia Rodrigues, Karen R Lausch, Cesario L Martins, Ane B Fisker, and Peter Aaby. “Two Different Doses of Supplemental Vitamin A Did Not Affect Mortality of Normal-Birth-Weight Neonates in Guinea-Bissau in a Randomized Controlled Trial.” The Journal of Nutrition 144, no. 9 (September 2014): 1474–79. doi:10.3945/jn.114.192674.
    • Vancouver/ICMJE:
      Benn CS, Diness BR, Balde I, Rodrigues A, Lausch KR, Martins CL, et al. Two different doses of supplemental vitamin A did not affect mortality of normal-birth-weight neonates in Guinea-Bissau in a randomized controlled trial. The Journal of nutrition [Internet]. 2014 Sep [cited 2020 Sep 20];144(9):1474–9. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=24991044&authtype=sso&custid=s5834912