The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study.

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  • Additional Information
    • Subject Terms:
    • Keyword(s):
      Dietary sucrose; Fructose; Liver enzymes; Menstrual cycle; Sugar-sweetened beverages
    • Abstract:
      Purpose: To prospectively assess the association between sugar-sweetened beverages (SSB), added sugar, and total fructose and serum concentrations of liver enzymes among healthy, reproductive-age women. Methods: A prospective cohort of 259 premenopausal women (average age 27.3 ± 8.2 years; BMI 24.1 ± kg/m) were followed up for up to two menstrual cycles, providing up to eight fasting blood specimens/cycle and four 24-h dietary recalls/cycle. Women with a history of chronic disease were excluded. Alanine and aspartate aminotransferases (ALT and AST, respectively) were measured in serum samples. Linear mixed models estimated associations between average SSB, added sugar, and total fructose intake and log-transformed liver enzymes adjusting for age, race, body mass index, total energy and alcohol intake, and Mediterranean diet score. Results: For every 1 cup/day increase in SSB consumption and 10 g/day increase in added sugar and total fructose, log ALT increased by 0.079 U/L (95 % CI 0.022, 0.137), 0.012 U/L (95 % CI 0.002, 0.022), and 0.031 (0.012, 0.050), respectively, and log AST increased by 0.029 U/L (−0.011, 0.069), 0.007 U/L (0.000, 0.014), and 0.017 U/L (0.004, 0.030), respectively. Women who consumed ≥1.50 cups/day (12 oz can) SSB versus less had 0.127 U/L (95 % CI 0.001, 0.254) higher ALT [percent change 13.5 % (95 % CI 0.1, 28.9)] and 0.102 (95 % CI 0.015, 0.190) higher AST [percent change 10.8 % (95 % CI 1.5, 20.9)]. Conclusions: Sugar-sweetened beverages were associated with higher serum ALT and AST concentrations among healthy premenopausal women, indicating that habitual consumption of even moderate SSB may elicit hepatic lipogenesis. ABSTRACT FROM AUTHOR
    • Author Affiliations:
      1 Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, 7B03M Rockville 20852 USA; 2 Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville USA; 3 Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax USA; 4 Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo USA
    • ISSN:
      14366207
    • Publication Type:
      Publication Type: Article Update Code: 20160226
    • Accession Number:
      113305053
  • Citations
    • ABNT:
      SHIMONY, M. et al. The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study. European Journal of Nutrition, [s. l.], v. 55, n. 2, p. 569–576, 2016. Disponível em: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912. Acesso em: 10 jul. 2020.
    • AMA:
      Shimony M, Schliep K, Schisterman E, et al. The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study. European Journal of Nutrition. 2016;55(2):569-576. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912. Accessed July 10, 2020.
    • AMA11:
      Shimony M, Schliep K, Schisterman E, et al. The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study. European Journal of Nutrition. 2016;55(2):569-576. Accessed July 10, 2020. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912
    • APA:
      Shimony, M., Schliep, K., Schisterman, E., Ahrens, K., Sjaarda, L., Rotman, Y., Perkins, N., Pollack, A., Wactawski-Wende, J., & Mumford, S. (2016). The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study. European Journal of Nutrition, 55(2), 569–576.
    • Chicago/Turabian: Author-Date:
      Shimony, Maya, Karen Schliep, Enrique Schisterman, Katherine Ahrens, Lindsey Sjaarda, Yaron Rotman, Neil Perkins, Anna Pollack, Jean Wactawski-Wende, and Sunni Mumford. 2016. “The Relationship between Sugar-Sweetened Beverages and Liver Enzymes among Healthy Premenopausal Women: A Prospective Cohort Study.” European Journal of Nutrition 55 (2): 569–76. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912.
    • Harvard:
      Shimony, M. et al. (2016) ‘The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study’, European Journal of Nutrition, 55(2), pp. 569–576. Available at: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912 (Accessed: 10 July 2020).
    • Harvard: Australian:
      Shimony, M, Schliep, K, Schisterman, E, Ahrens, K, Sjaarda, L, Rotman, Y, Perkins, N, Pollack, A, Wactawski-Wende, J & Mumford, S 2016, ‘The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study’, European Journal of Nutrition, vol. 55, no. 2, pp. 569–576, viewed 10 July 2020, .
    • MLA:
      Shimony, Maya, et al. “The Relationship between Sugar-Sweetened Beverages and Liver Enzymes among Healthy Premenopausal Women: A Prospective Cohort Study.” European Journal of Nutrition, vol. 55, no. 2, Mar. 2016, pp. 569–576. EBSCOhost, widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912.
    • Chicago/Turabian: Humanities:
      Shimony, Maya, Karen Schliep, Enrique Schisterman, Katherine Ahrens, Lindsey Sjaarda, Yaron Rotman, Neil Perkins, Anna Pollack, Jean Wactawski-Wende, and Sunni Mumford. “The Relationship between Sugar-Sweetened Beverages and Liver Enzymes among Healthy Premenopausal Women: A Prospective Cohort Study.” European Journal of Nutrition 55, no. 2 (March 2016): 569–76. http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912.
    • Vancouver/ICMJE:
      Shimony M, Schliep K, Schisterman E, Ahrens K, Sjaarda L, Rotman Y, et al. The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study. European Journal of Nutrition [Internet]. 2016 Mar [cited 2020 Jul 10];55(2):569–76. Available from: http://widgets.ebscohost.com/prod/customlink/proxify/proxify.php?count=1&encode=0&proxy=&find_1=&replace_1=&target=http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=s3h&AN=113305053&authtype=sso&custid=s5834912